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Sitagliptin works tocompetitively inhibittheenzymedipeptidyl peptidase 4 (DPP-4). This enzyme breaks down theincretinsGLP-1and GIP,gastrointestinal hormonesreleased in response to a meal.By preventing breakdown of GLP-1 and GIP, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreasThis drives blood glucose levels towards normal
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