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Febuxostat is a potent, non-purine, selective inhibitor of xanthine oxidase (XO) that achieves its therapeutic effect of decreasing serum uric acid by selectively inhibiting xanthine oxidase. Uric acid is the end product of purine metabolism and is generated in the cascade of hypoxanthine ! xanthine ! uric acid. Both steps in the transformation are catalyzed by xanthine oxidase.
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